The Piccadilly Line is shown on the London Tube Map as a dark blue line. It serves 53 stations and handles over 176 million journeys every year over its 44-mile length. The line originally began as the Great Northern, Piccadilly & Brompton Railway and first opened in 1906, running from Finsbury Park to Hammersmith.

Image taken from the Piccadilly Line article on Wikipedia.
There have been many extensions of the line since it opened in 1906:
One of the trains on the Piccadilly line was attacked by the July 7th bombers in 2005. The train was between King's Cross and Russel Square when the explosion occurred.